ABSTRACT
Leucine-rich alpha-2 glycoprotein 1 (LRG1) is a highly conserved member of the family of leucine-rich repeat (LRR) proteins. LRG1 has been reported to be closely related to the occurrence and development of malignant tumors. Recent studies have shown that LRG1 is abnormally expressed in many digestive system tumors, including esophageal cancer, gastric cancer, liver cancer, pancreatic cancer, and colorectal cancer. LRG1 has also been reported to be closely related to tumor cell proliferation, invasion, migration, apoptosis, and poor prognosis. This paper reviews the research progress of LRG1 in many digestive system tumors, providing new ideas for LRG1-based anti-tumor treatment.
ABSTRACT
Objective By studying the variation of individual urinary iodine concentration due to different ways of urine sample collection to optimize it for standard clinical evaluation.Methods Totally 20 healthy adults were recruited and their urine samples were collected as a random urine sample within 1 day,the 24 hour urine and morning urine samples within 5 successive days,respectively.The coefficient of variation in each group was calculated.Paired t test was used to compare the results of 24 hour urine with the results of random urine and that of morning urine samples,respectively.Results The range of individual coefficient of variation for random urine sample within one day was 12.5％-57.4％,while most of the coefficients of variation were around 30.39％.In contrast,the individual coefficients of variation of morning urine sample and 24 hour urine results within 5 days were 5.4％-26.0％ and 3.4％-16.6％ and most of them were at about 11.74％ and 7.91％.The paired t test showed that the results of random urine sample were significantly different compared with that of 24 hour urine (t =-4.231,P ＜ 0.05).On the other hand,there was also significant difference for the results of morning urine compared with that of 24 hour urine (t =3.884,P ＜ 0.05).Conclusion This study suggests that 24 hour urine is the most appropriate way of sample collection for individualized detection of urinary iodine.
ABSTRACT
Objective To understand the characteristics of High-density lipoprotein cholesterol (HDL-C) distribution through analyzing serum HDL-C levels in healthy checkup subjects among local urbanese.Methods The checkup results of 36 454 cases were collected from 2009 to 2013 in Tangshan Gongren hospital (male:n =20 343,female:n =16 111).The cases with liver injury,abnormal blood glucoses,kidney injury and defined cerebrovascular diseases and metabolic disease were excluded.25 197 cases were analyzed as normal subjects including 11 114 males and 14 083 females.Kolmogorov-Smimov test,kruskal-wallis test,and Dunn multiple comparison test was performed using Bioconductor software 3.0.2 for testing normality distribution and comparing the difference of two or multiple groups,respectively.Results were analyzed statistically with R 3.0.2.Results The results showed that the average level (1.22-± 0.31) mmol/L of HDL-C among the overall population is lower than that of national average level(1.30 mmol/L).The median serum HDL-C level in female is higher than in male (1.27 and 1.08,x2 =2 606.34,P ＜0.01).HDL-C levels in male continuously increase from 1.06 mmol/L to 1.11 mmol/L with aging,especially in groups of over 50 years old than in groups of below 50 years old (x2 =75.19,P ＜ 0.01).Conclusions Based on 2007 guidance on prevention and treatment by national health bureau,this study showed that there are 29.69％ of the apparent healthy subjects,especially about 42.94％ of the male,representing low HDL-C level under the low limit of 1.04 mmol/L.These results showed that serum HDL-C level in Tangshan urbanese is lower than that of national average level,and HDL-C level in male is tended to increase with aging.